monoclonal antibody

noun

plural monoclonal antibodies

: an antibody that is derived from the clone of a single B cell and that is produced in large quantities of identical cells possessing affinity for the same epitope on a specific antigen (as a cancer cell)

Note: Monoclonal antibodies are typically used in immunotherapy (such as in the treatment of autoimmune or inflammatory disorders and cancer), diagnostic testing, and cell identification and tracing. Hybridoma cell lines are typically employed to produce an unlimited supply of monoclonal antibodies.

Researchers studying this and other cancers have long sought to use monoclonal antibodies—biological molecules that bind only to particular target cells—to attack tumors directly or to shuttle toxins selectively to cancer cells.

—R. Weiss

The ideal immunosuppressive monoclonal antibody would be one that abrogates responses to a defined antigen and preserves responses to all others.

—Thomas A. Waldmann

The drug, which would be given by intravenous infusion every four weeks, is a monoclonal antibody that tamps down the immune system …

—Andrew Pollack

—abbreviation Mab, mAb, MAB, mab

Examples of monoclonal antibody in a Sentence

Recent Examples on the Web

But that was before the arrival of teplizumab, a monoclonal antibody approved in late 2022 that delays the advance of the illness and may even halt it at stage 2 in some people. —Tara Haelle, Scientific American, 14 Oct. 2025

The 26-week CBeyond study tested the drug, a first-in-class monoclonal antibody that blocks the CB1 receptors, either alone or alongside semaglutide (the active ingredient in Wegovy). —New Atlas, 12 Oct. 2025

The life-saving medication is made from monoclonal antibodies that target the HER2 gene that is often amplified during early-stage breast cancers. —Andrew Paul, Popular Science, 8 Oct. 2025

In another experimental procedure run by the World Health Organization and others, Firew and colleagues gave him the first ever infusion of monoclonal antibodies for a Marburg patient. —Gabrielle Emanuel, NPR, 6 Oct. 2025

Word History

First Known Use

1967, in the meaning defined above

Rhymes for monoclonal antibody

• afterbody
• busybody
• everybody
• autoantibody
• bawdy
• body
• gaudy
• khadi
• mahdi
• noddy
• oddi
• shoddy

Medical Definition

monoclonal antibody

noun

: an antibody that is derived from the clone of a single B cell and that is produced in large quantities of identical cells possessing affinity for the same epitope on a specific antigen (as a cancer cell)

Note: Monoclonal antibodies are typically used in immunotherapy (such as in the treatment of autoimmune or inflammatory disorders and cancer), diagnostic testing, and cell identification and tracing. Hybridoma cell lines are typically employed to produce an unlimited supply of monoclonal antibodies.

Monoclonal antibodies have largely been applied clinically to the diagnosis and therapy of cancer and the modulation of the immune response to produce immunosuppression for treatment of autoimmune and graft versus host diseases (GVHD) and for prevention of allograft rejection.

—Thomas A. Walmann, Science

Monoclonal antibodies can distinguish and single out a specific protein from the other molecules around it. Monoclonal antibodies are versatile and can assist in the identification, tracking, and alteration of specific proteins.

—Maryann Bozzette, Journal of Perinatal & Neonatal Nursing

—abbreviation MAb, mAb, MAB, mab